The notes indicate that both Deferiprone and Deferasirox cause which of the following?

The notes indicate that both Deferiprone and Deferasirox cause which of the following?

• A. GI side effects and elevated liver enzymes
• B. Hepatotoxicity and pancreatitis
• C. Neurologic symptoms and seizures
• D. No adverse effects

Answer: (A)

Both deferiprone and deferasirox are oral iron chelators whose most common adverse effects include gastrointestinal symptoms (nausea, abdominal pain, diarrhea) and elevations in liver enzymes indicating potential liver injury. This pattern is repeatedly seen with these agents, and it guides the need for regular monitoring of liver function tests during therapy. While each drug has additional risks (for example, deferiprone can cause neutropenia and deferasirox can affect renal function), the shared, characteristic adverse effects described here are GI upset and elevated liver enzymes, making this option the best match.

Both deferiprone and deferasirox are oral iron chelators whose most common adverse effects include gastrointestinal symptoms (nausea, abdominal pain, diarrhea) and elevations in liver enzymes indicating potential liver injury. This pattern is repeatedly seen with these agents, and it guides the need for regular monitoring of liver function tests during therapy. While each drug has additional risks (for example, deferiprone can cause neutropenia and deferasirox can affect renal function), the shared, characteristic adverse effects described here are GI upset and elevated liver enzymes, making this option the best match.