Which option correctly lists the four strong thrombophilias?

Which option correctly lists the four strong thrombophilias?

• A. Antithrombin deficiency; Protein C deficiency; Factor V Leiden; Prothrombin G20210A
• B. APLA syndrome; Anti-thrombin deficiency; Protein C deficiency; Protein S deficiency
• C. APLA syndrome; Anti-thrombin deficiency; Factor V Leiden; Protein S deficiency
• D. Protein C deficiency; Protein S deficiency; Factor V Leiden; Prothrombin G20210A

Answer: (B)

The strongest thrombophilias include an acquired autoimmune thrombophilia and the three main inherited deficiencies of natural anticoagulants. Antiphospholipid syndrome is a prominent acquired cause of hypercoagulability, carrying a high risk of both arterial and venous thrombosis. When combined with the three major inherited deficiencies—antithrombin deficiency, protein C deficiency, and protein S deficiency—you get a set that represents the most powerful overall thrombophilic states described in many exam contexts. Other options swap in Factor V Leiden or Prothrombin G20210A, which are important risk factors but are not consistently classified as among the four strongest in the same way, and they omit one of the key inherited deficiencies. Therefore, pairing antiphospholipid syndrome with antithrombin, protein C, and protein S deficiencies best fits the standard high-risk quartet used in this question.

The strongest thrombophilias include an acquired autoimmune thrombophilia and the three main inherited deficiencies of natural anticoagulants. Antiphospholipid syndrome is a prominent acquired cause of hypercoagulability, carrying a high risk of both arterial and venous thrombosis. When combined with the three major inherited deficiencies—antithrombin deficiency, protein C deficiency, and protein S deficiency—you get a set that represents the most powerful overall thrombophilic states described in many exam contexts. Other options swap in Factor V Leiden or Prothrombin G20210A, which are important risk factors but are not consistently classified as among the four strongest in the same way, and they omit one of the key inherited deficiencies. Therefore, pairing antiphospholipid syndrome with antithrombin, protein C, and protein S deficiencies best fits the standard high-risk quartet used in this question.